Description

4-Ethoxy-2,3-Difluorobenzenesulfonylchloride is a high-purity, multi-functional chemical intermediate essential for advanced organic synthesis. Its core value lies in its reactive sulfonyl chloride group, which serves as a versatile building block for constructing complex sulfonamide and sulfonate derivatives. This compound is primarily needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoroethoxy moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functional polymers and liquid crystals, contributing to the development of new electronic and optical materials.
• Chemical Biology Probes: Employed in the creation of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a specific, fluorinated benzenesulfonyl scaffold.

Basic Information

Product Name	4-Ethoxy-2,3-Difluorobenzenesulfonylchloride
CAS No.	293299-90-8
Molecular Formula	C8H7ClF2O3S
Molecular Weight	256.66 g/mol
Synonyms	2,3-Difluoro-4-ethoxybenzenesulfonyl chloride; 1-Ethoxy-2,3-difluoro-4-(chlorosulfonyl)benzene; 4-Ethoxy-2,3-difluorobenzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 4-ethoxy-2,3-difluoro-; 293299-90-8; 4-Ethoxy-2,3-difluoro phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2,3-Difluorobenzenesulfonylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.