Description

L-685 458 is a potent and selective small molecule inhibitor of γ-secretase, a key enzyme complex involved in the processing of amyloid precursor protein. This compound is of significant value for biochemical and pharmaceutical research, particularly in the study of Alzheimer's disease pathways and Notch signaling. It is primarily utilized by researchers in academic institutions, biotechnology firms, and pharmaceutical R&D departments focused on neurodegenerative diseases and oncology.

Application

• Biochemical Research: A critical tool for inhibiting γ-secretase activity in cell-based and in vitro assays to study amyloid-beta peptide production.
• Neuroscience Studies: Used to investigate the molecular mechanisms underlying Alzheimer's disease and other amyloidogenic disorders.
• Oncology Research: Applied in studies targeting the Notch signaling pathway, which is implicated in various cancers and cell differentiation processes.
• Drug Discovery: Serves as a reference compound and pharmacological probe in high-throughput screening and lead optimization programs for secretase inhibitors.
• Academic & Pharmaceutical R&D: Essential for basic research and preclinical development within molecular biology and medicinal chemistry laboratories.

Basic Information

Product Name	L-685 458
CAS No.	292632-98-5
Molecular Formula	C₂₃H₂₆N₄O₄
Molecular Weight	422.48 g/mol
Synonyms	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-N-[(1S,2R)-1-hydroxy-2,3-dihydro-1H-inden-2-yl]pentanediamide; L685,458; L-685,458; γ-Secretase Inhibitor L-685,458; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(3H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-N-[(1S,2R)-1-hydroxy-2,3-dihydro-1H-inden-2-yl]pentanediamide
EINECS	Contact for details

Quality Control

Our L-685 458 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not intended for human or veterinary therapeutic use, production adheres to principles of current Good Manufacturing Practice (cGMP) where applicable for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.