Description

1-(Chloromethyl)-2,3,4-Trifluorobenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its ability to introduce both a reactive chloromethyl group and a trifluorinated phenyl moiety into target molecules, enabling the creation of complex chemical architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs), influencing dielectric anisotropy and stability.
• Functional Material Development: Employed in the research and production of advanced polymers, organic semiconductors, and specialty coatings.
• Cross-Coupling Reactions: The chloromethyl group acts as a handle for further functionalization via Suzuki, Heck, or other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A valuable reagent for exploring new synthetic pathways and creating novel fluorinated compounds in academic and industrial labs.

Basic Information

Product Name	1-(Chloromethyl)-2,3,4-Trifluorobenzene
CAS No.	292621-60-4
Molecular Formula	C7H4ClF3
Molecular Weight	192.56 g/mol
Synonyms	2,3,4-Trifluorobenzyl Chloride; (2,3,4-Trifluorophenyl)methyl Chloride; α-Chloro-2,3,4-trifluorotoluene; 2,3,4-Trifluoro-1-(chloromethyl)benzene; 1-(Chloromethyl)-2,3,4-trifluorobenzene; 2,3,4-Trifluorobenzylchloride; Benzene, 1-(chloromethyl)-2,3,4-trifluoro-
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-2,3,4-Trifluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. The container should be kept tightly sealed to prevent moisture ingress and to contain its organic solvent nature.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.