Description

Abcb1 CAS NO 292171-04-1 is a high-purity chemical compound widely utilized in advanced pharmaceutical and biochemical research. Its primary value lies in its role as a potent and selective inhibitor of the P-glycoprotein efflux pump, a key target in overcoming multidrug resistance (MDR) in cancer therapy. This makes it an essential research tool for scientists in oncology, pharmacology, and drug discovery, enabling critical studies on drug transport, bioavailability, and therapeutic efficacy.

Application

• Multidrug Resistance (MDR) Research: Used as a reference standard and active inhibitor to study the function and modulation of the ABCB1 (P-gp) transporter in cancer cell lines.
• Drug-Drug Interaction Studies: Employed in in vitro assays to investigate potential interactions between new chemical entities and the P-gp transport system, a critical step in preclinical ADME/Tox profiling.
• Pharmacokinetics Enhancement: Applied in research aimed at improving the oral bioavailability and brain penetration of co-administered therapeutic agents by temporarily inhibiting intestinal and blood-brain barrier P-gp.
• Mechanistic Biochemistry: Serves as a key reagent for elucidating the ATP-binding and hydrolysis mechanisms of ABC transporter proteins.
• High-Throughput Screening (HTS): Utilized as a control compound in screening campaigns to identify novel P-gp inhibitors or substrates.
• Academic & Institutional Research: Fundamental tool for universities and research institutes studying membrane transport physiology and pathophysiology.

Basic Information

Product Name	Abcb1
CAS No.	292171-04-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	P-glycoprotein inhibitor; ABCB1 inhibitor; P-gp Inhibitor; Multidrug resistance inhibitor 1; (2R)-anti-5-{3-[4-(10,11-Difluoromethanodibenzo-suber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline trihydrochloride; GF120918 analog; Elacridar analog
EINECS	Contact for details

Quality Control

Our Abcb1 (CAS 292171-04-1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.