Description

Mcl1-In-2 CAS NO 292057-76-2 is a potent and selective small-molecule inhibitor of the myeloid cell leukemia 1 (Mcl-1) protein, a key anti-apoptotic regulator in the Bcl-2 family. This compound is a critical research tool for investigating programmed cell death pathways and their role in cancer biology and therapeutic resistance. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and the development of novel apoptosis-targeting therapies.

Application

• Biochemical Research: Used as a selective probe to study the function and inhibition mechanisms of the Mcl-1 protein in apoptotic signaling pathways.
• Oncology Drug Discovery: Serves as a reference compound and a starting point for the design and optimization of novel Mcl-1 inhibitors for cancer treatment.
• Cell Biology Studies: Employed in in vitro cell-based assays to evaluate the effects of Mcl-1 inhibition on cancer cell proliferation, survival, and sensitivity to other chemotherapeutic agents.
• Mechanism of Action (MoA) Validation: Aids in validating the role of Mcl-1 in specific cancer types and in understanding resistance mechanisms to Bcl-2 family-targeted therapies.
• High-Throughput Screening (HTS): Can be used as a control or standard in screening campaigns to identify new chemical entities with Mcl-1 inhibitory activity.

Basic Information

Product Name	Mcl1-In-2
CAS No.	292057-76-2
Molecular Formula	C₂₀H₂₀ClN₅O₂
Molecular Weight	397.86 g/mol
Synonyms	Mcl1-In-2; Mcl-1 inhibitor 2; 4-(4-((4-(2-Chlorophenyl)piperazin-1-yl)methyl)piperidin-1-yl)-N-(pyridin-4-yl)benzamide; Benzamide, 4-[4-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-1-piperidinyl]-N-4-pyridinyl-; Mcl-1 Inhibitor, Selective; Mcl-1 antagonist; Apoptosis inducer via Mcl-1 inhibition
EINECS	Contact for details

Quality Control

Our Mcl1-In-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC, identity confirmation (IR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.