Description

Ac-Tyr-(Nme)Val-Ala-(Nme)Asp-Cho is a specialized, high-purity peptide derivative used in advanced biochemical research and pharmaceutical development. This compound serves as a critical tool for studying enzyme mechanisms, particularly in the context of protease inhibition and substrate specificity. It is essential for researchers and developers in the fields of medicinal chemistry, proteomics, and drug discovery who require precise, well-characterized biochemical probes.

Application

• Protease Inhibitor Research: Used as a synthetic substrate or inhibitor to study the activity and kinetics of specific proteolytic enzymes, including caspases and other aspartic proteases.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate or reference standard in the design and screening of novel therapeutic agents targeting protease-related diseases.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays and diagnostic kits for enzymatic activity.
• Academic & Institutional Research: Provides a crucial reagent for fundamental studies in cell biology, apoptosis (programmed cell death), and signal transduction pathways.
• Peptide Synthesis & Modification Studies: Acts as a model compound for investigating peptide stability, N-methylation effects on bioavailability, and structure-activity relationships (SAR).

Basic Information

Product Name	Ac-Tyr-(Nme)Val-Ala-(Nme)Asp-Cho
CAS No.	290814-90-3
Molecular Formula	C30H43N5O9
Molecular Weight	617.70 g/mol
Synonyms	Acetyl-Tyrosyl-N-methyl-Valyl-Alanyl-N-methyl-Aspartyl-aldehyde; Ac-Y(NMe)V-A(NMe)D-CHO; Caspase Inhibitor Peptide; N-Acetyl-L-tyrosyl-N-methyl-L-valyl-L-alanyl-N-methyl-L-α-aspartyl aldehyde; Ac-Tyr-(N-Me)Val-Ala-(N-Me)Asp-H; Ac-YVAD-CHO (N-methylated analog); N-Acetyl-Tyr-N-methyl-Val-Ala-N-methyl-Asp-1-al
EINECS	Contact for details

Quality Control

Every batch of Ac-Tyr-(Nme)Val-Ala-(Nme)Asp-Cho is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting critical research and development work. A detailed Certificate of Analysis (COA) including HPLC purity, mass spectrometry (MS) confirmation, and NMR data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be kept under desiccant and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.