Description

Senicapoc is a potent and selective inhibitor of the Gardos channel (IKCa), a calcium-activated potassium channel. This targeted pharmacological action makes it a critical research tool and a promising candidate for therapeutic development, particularly in hematological disorders. It is essential for researchers and pharmaceutical developers in the fields of sickle cell disease and red blood cell physiology.

Application

• Pharmacological Research: A key reference standard and active compound for studying the role of the Gardos channel in cellular volume regulation and membrane potential.
• Sickle Cell Disease (SCD) Research: Investigated for its potential to reduce red blood cell dehydration, a major contributor to sickling and hemolysis in SCD.
• Preclinical Development: Used in in vitro and in vivo models to evaluate efficacy and pharmacokinetics for potential therapeutic applications.
• Biochemical Assays: Employed in high-throughput screening and functional assays to identify and characterize other modulators of IKCa channels.
• Mechanistic Studies: Utilized to elucidate ion channel physiology and pathophysiology in various cell types beyond erythrocytes.

Basic Information

Product Name	Senicapoc
CAS No.	289656-45-7
Molecular Formula	C21H23N3O3S
Molecular Weight	397.49 g/mol
Synonyms	ICA-17043; Senicapoc (ICA-17043); 2,2-Bis(4-fluorophenyl)-2H,4H,9H-pyrano[3,4-b]thieno[2,3-e]pyran-9-one; Gardos Channel Inhibitor ICA-17043; N-[(3S)-2,2-Bis(4-fluorophenyl)-4,9-dioxo-2H,4H,9H-pyrano[3,4-b]thieno[2,3-e]pyran-3-yl]-N-methylacetamide
EINECS	Contact for details

Quality Control

Our Senicapoc is manufactured under strict quality systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.