Description

Vegfr2 Kinase Inhibitor Ii CAS NO 288144-20-7 is a potent and selective small molecule inhibitor targeting the Vascular Endothelial Growth Factor Receptor 2 (VEGFR2/KDR), a key protein in angiogenesis signaling pathways. This compound is a critical research tool for studying tumor growth, metastasis, and for the preclinical development of novel anti-cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, cardiovascular disease, and ophthalmology research.

Application

• Biochemical Research: Used as a reference standard and pharmacological probe to study VEGFR2-mediated signal transduction and downstream effects in cell-based assays.
• Drug Discovery & Development: Serves as a lead compound or positive control in high-throughput screening (HTS) campaigns and structure-activity relationship (SAR) studies for novel kinase inhibitors.
• Oncology Research: Employed in in vitro and in vivo models to investigate angiogenesis inhibition as a strategy to halt tumor progression and metastasis.
• Academic Studies: Facilitates fundamental research into the role of VEGF/VEGFR2 pathways in physiological and pathological processes beyond cancer, such as macular degeneration and wound healing.
• Preclinical Testing: Acts as a benchmark compound for evaluating the efficacy and selectivity of new anti-angiogenic drug candidates in animal models.

Basic Information

Product Name	Vegfr2 Kinase Inhibitor Ii
CAS No.	288144-20-7
Molecular Formula	C₂₁H₁₉N₅O₄
Molecular Weight	405.41 g/mol
Synonyms	VEGFR2 Kinase Inhibitor II; SU1498; 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one; 5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; Tyrphostin SU 1498; KDR Kinase Inhibitor; SU-1498; VEGF Receptor 2 Inhibitor II
EINECS	Contact for details

Quality Control

Our Vegfr2 Kinase Inhibitor Ii is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.