Description

4,4'-Diamino-15N2-Diphenyl Sulfone is a stable isotope-labeled analog of dapsone, where two nitrogen atoms are enriched with the 15N isotope. This compound is essential for advanced analytical and research applications requiring precise molecular tracking and quantification. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers of diagnostic standards who require high-purity, isotopically labeled materials for mass spectrometry, metabolic studies, and internal standard development.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Used as a quantitative reference standard in bioanalytical methods for drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolic Pathway Tracing: Enables the study of dapsone's biotransformation and metabolic fate in biological systems using isotope ratio monitoring.
• Pharmaceutical Impurity Profiling: Serves as a critical tool in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Diagnostic Kit Manufacturing: Incorporated into calibrators and controls for in-vitro diagnostic (IVD) assays to ensure accurate measurement of dapsone or related compounds.
• Stable Isotope Labeled Compound Synthesis: Acts as a key building block for synthesizing more complex 15N-labeled molecules for research.
• Environmental and Forensic Analysis: Applied in sophisticated analytical methods to detect and quantify sulfone compounds in complex matrices.

Basic Information

Product Name	4,4'-Diamino-15N2-Diphenyl Sulfone
CAS No.	287476-19-1
Molecular Formula	C12H1215N2O2S
Molecular Weight	250.29 g/mol (for 15N2 form)
Synonyms	Dapsone-15N2; 4,4'-Sulfonyldianiline-15N2; 15N2-Dapsone; 4,4'-Diaminodiphenyl Sulfone-15N2; DDS-15N2; Bis(4-aminophenyl) Sulfone-15N2; Avlosulfon-15N2
EINECS	Contact for details

Quality Control

Our 4,4'-Diamino-15N2-Diphenyl Sulfone is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 15N), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry guidelines for stable isotope-labeled compounds to ensure consistency and reliability for your critical research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 15N)	≥ 98%
Purity (HPLC)	≥ 98.0%
Chemical Purity (Titration)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.