Description

Apratastat CAS NO 287405-51-0 is a potent and selective small molecule inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP-2, MMP-9, and MMP-13. This compound is of significant interest in pharmaceutical research for its potential to modulate extracellular matrix degradation, a key process in various pathological conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for cancer metastasis, inflammatory diseases, and tissue remodeling disorders.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of novel MMP inhibitors.
• Oncology Research: Investigation of mechanisms and potential treatments for tumor invasion, angiogenesis, and metastasis where MMP activity is upregulated.
• Inflammatory Disease Models: Used in preclinical studies for conditions like rheumatoid arthritis, osteoarthritis, and atherosclerosis to study MMP-mediated tissue destruction.
• Biochemical Assay Development: Serves as a critical control compound in high-throughput screening (HTS) assays to identify and characterize new MMP inhibitors.
• Academic Research: Tool compound for studying the role of specific MMPs in cellular signaling pathways, wound healing, and developmental biology.

Basic Information

Product Name	Apratastat
CAS No.	287405-51-0
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	Apratastat; TMI-1; TMI 1; (2R)-2-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-methylbutanamide; N-Hydroxy-2-[(4-phenylphenyl)sulfonyl]amino-3-methylbutanamide; (R)-2-(([1,1'-Biphenyl]-4-ylsulfonyl)amino)-N-hydroxy-3-methylbutanamide; TMI-005; MMP Inhibitor III
EINECS	Contact for details

Quality Control

Our Apratastat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.