Description

4-Hydroxybenzoic Acid-13C7 is a stable isotope-labeled analog of 4-hydroxybenzoic acid, where seven carbon atoms are replaced with the carbon-13 (13C) isotope. This compound is essential as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of its unlabeled counterpart in complex biological and chemical matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, food safety, and environmental analysis sectors, where reliable quantification is paramount for method validation, pharmacokinetic studies, and regulatory compliance.

Application

• Quantitative Mass Spectrometry (MS): Serves as a high-purity internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify metabolites derived from 4-hydroxybenzoic acid or related compounds.
• Biochemical Pathway Analysis: Enables tracing of metabolic fluxes in studies involving the shikimate or benzoic acid pathways in plants and microorganisms.
• Food and Beverage Analysis: Facilitates accurate measurement of parabens (esters of 4-hydroxybenzoic acid) and related preservatives for safety and quality control.
• Environmental Monitoring: Applied in the detection and quantification of phenolic pollutants and their degradation products in water and soil samples.
• Clinical Diagnostics: Supports the development of diagnostic assays for inborn errors of metabolism involving aromatic acid intermediates.
• Method Development and Validation: Provides a reference for establishing and validating analytical methods to meet ICH, FDA, and other regulatory guidelines.

Basic Information

Product Name	4-Hydroxybenzoic Acid-13C7
CAS No.	287399-28-4
Molecular Formula	13C7H6O3
Molecular Weight	~143.1 g/mol (for 13C7)
Synonyms	p-Hydroxybenzoic Acid-13C7; 4-Carboxyphenol-13C7; Benzoic-13C7 acid, 4-hydroxy-; Paraben-13C7 Precursor; PHBA-13C7; Isotopically Labeled 4-Hydroxybenzoic Acid; [13C7]-4-Hydroxybenzoic Acid; 13C7-4-HBA
EINECS	Contact for details

Quality Control

Our 4-Hydroxybenzoic Acid-13C7 is manufactured under strict quality systems to ensure the high isotopic and chemical purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reproducibility and reliability in your sensitive analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which could affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C7)	≥ 99 atom % 13C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.