Description

Scriptaid CAS NO 287383-59-9 is a potent and selective inhibitor of histone deacetylase (HDAC) enzymes, specifically targeting Class I and II HDACs. This compound is a critical research tool for modulating gene expression and chromatin structure, enabling the study of epigenetic regulation in various biological contexts. It is primarily utilized by researchers and scientists in the fields of oncology, neurology, and molecular biology for drug discovery and mechanistic studies.

Application

• Epigenetic Research: A key reagent for investigating histone acetylation, chromatin remodeling, and gene silencing mechanisms.
• Cancer Biology Studies: Used to induce cell cycle arrest, differentiation, and apoptosis in various cancer cell lines to explore novel therapeutic pathways.
• Neuroscience Research: Employed in models of neurodegenerative diseases to study the role of HDACs in neuronal survival, memory, and synaptic plasticity.
• Stem Cell Research: Facilitates the study of epigenetic reprogramming and the maintenance of pluripotency in stem cells.
• Inflammation & Immunology: Applied to examine the epigenetic control of inflammatory cytokine production and immune cell function.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening for HDAC inhibitor activity.

Basic Information

Product Name	Scriptaid
CAS No.	287383-59-9
Molecular Formula	C₂₀H₂₂N₄O₄
Molecular Weight	382.41 g/mol
Synonyms	N-Hydroxy-4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]benzamide; HDAC Inhibitor VIII; NSC 366140; Suberoylanilide Hydroxamic Acid (SAHA) analog; HDAC inhibitor Scriptaid; 4-[[[2-(1H-Indol-3-yl)ethyl](2-hydroxyethyl)amino]methyl]-N-hydroxybenzamide
EINECS	Contact for details

Quality Control

Our Scriptaid is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.