Description

4-Chloro-2,5-Difluorobenzenesulfonyl Chloride is a high-purity, multi-functional chemical intermediate essential for advanced organic synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and halogenated aromatic ring—which enable precise and efficient derivatization. This compound is critically needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides that require specific halogenated sulfonyl motifs.
• Material Science: Serves as a precursor for creating specialized polymers, dyes, and liquid crystal materials.
• Chemical Research: A versatile reagent in academic and industrial laboratories for exploring new reaction pathways and creating novel chemical entities.
• Custom Synthesis: Employed in contract manufacturing for the tailored production of complex, high-value specialty chemicals.

Basic Information

Product Name	4-Chloro-2,5-Difluorobenzenesulfonyl Chloride
CAS No.	286932-78-3
Molecular Formula	C6H2Cl2F2O2S
Molecular Weight	247.04 g/mol
Synonyms	2,5-Difluoro-4-chlorobenzenesulfonyl chloride; 1-Chloro-2,5-difluoro-4-sulfonylchloridebenzene; Benzenesulfonyl chloride, 4-chloro-2,5-difluoro-; 4-Chloro-2,5-difluorobenzene-1-sulfonyl chloride; 286932-78-3; 4-Chloro-2,5-difluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.