Description

1-Bromo-2-Fluoro-5-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethoxy group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores in electronic materials, improving charge transport and thermal stability.
• Cross-Coupling Reactions: The bromine substituent acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and developing new fluorination methodologies.
• Polymer Modification: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance and specific optical properties.

Basic Information

Product Name	1-Bromo-2-Fluoro-5-(Trifluoromethoxy)Benzene
CAS No.	286932-57-8
Molecular Formula	C7H3BrF4O
Molecular Weight	259.00 g/mol
Synonyms	2-Fluoro-5-(trifluoromethoxy)bromobenzene; 5-Bromo-2-fluoro-1-(trifluoromethoxy)benzene; Benzene, 1-bromo-2-fluoro-5-(trifluoromethoxy)-; 1-Bromo-2-fluoro-5-(trifluoromethoxy)benzene; 2-Fluoro-α,α,α-trifluoro-5-bromoanisole; 5-Bromo-2-fluoroanisole, α,α,α-trifluoro-; 286932-57-8
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-Fluoro-5-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and quality assurance documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.8 g/cm³
Boiling Point	~185-190°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.