Description

Iodoacetic Acid-1-13C is a stable isotope-labeled derivative of iodoacetic acid, where the carbon-1 position is enriched with the 13C isotope. This precise labeling is critical for advanced analytical research, enabling highly accurate metabolic pathway tracing and protein structure elucidation via techniques like mass spectrometry and NMR. It is an essential biochemical tool for researchers and developers in the fields of pharmaceutical development, proteomics, and metabolic studies who require definitive molecular tracking.

Application

• Biochemical Research & Proteomics: Used as an alkylating agent for selective cysteine modification in protein structure-function studies and peptide mapping.
• Metabolic Pathway Analysis: Serves as a 13C-labeled tracer to study glycolysis and other metabolic fluxes in cellular systems.
• Pharmaceutical Development: Employed in the synthesis and metabolic fate studies of novel drug candidates requiring isotopic labeling.
• Mass Spectrometry (MS) Standards: Acts as an internal standard for the quantitative analysis of carboxylic acids and related metabolites.
• NMR Spectroscopy: Provides a distinct 13C signal for structural analysis and dynamic studies of biomolecules.
• Enzyme Inhibition Studies: Used to investigate the mechanism of glycolytic enzymes like glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

Basic Information

Product Name	Iodoacetic Acid-1-13C
CAS No.	286367-80-4
Molecular Formula	C13CH2ICOOH
Molecular Weight	186.95 g/mol (for 13C1)
Synonyms	1-13C-Iodoacetic Acid; (1-13C)Monoiodoacetic Acid; 2-Iodoacetic-1-13C Acid; Iodo[1-13C]acetic Acid; IAA-1-13C; [1-13C]Iodoacetic Acid; Carboxy-13C iodoacetic acid; 13C Labeled Iodoacetic Acid
EINECS	Contact for details

Quality Control

Every batch of Iodoacetic Acid-1-13C is produced and analyzed under strict quality protocols to ensure high isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including isotopic enrichment analysis by NMR and quantitative purity assessment by HPLC. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Melting Point	80 - 83 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.