Description

Doramapimod is a potent and selective small-molecule inhibitor of p38 mitogen-activated protein (MAP) kinase, a key signaling protein involved in inflammatory pathways. This compound is of significant interest for its potential to modulate cytokine production and cellular responses associated with various inflammatory and autoimmune conditions. It serves as a critical research tool and pharmaceutical intermediate for scientists and developers in the pharmaceutical, biotechnology, and life science research sectors.

Application

• Biomedical Research: Used as a selective p38 MAP kinase inhibitor to study inflammatory signaling pathways, cytokine release, and apoptosis in cellular and animal models.
• Drug Discovery & Development: Serves as a key reference standard, pharmacologically active compound (PAC), and intermediate in the development of novel anti-inflammatory therapeutics.
• Mechanistic Studies: Employed to investigate the role of p38α and p38β isoforms in diseases such as rheumatoid arthritis, Crohn's disease, psoriasis, and other autoimmune disorders.
• High-Throughput Screening (HTS): Utilized as a control compound in assay development and validation for screening compound libraries targeting kinase activity.
• Academic Research: A vital reagent for universities and research institutes exploring molecular immunology, signal transduction, and novel therapeutic targets.

Basic Information

Product Name	Doramapimod
CAS No.	285983-48-4
Molecular Formula	C₂₀H₂₀FN₃O₂
Molecular Weight	353.39 g/mol
Synonyms	BIRB 796; BIRB-796; BIRB 796 BS; Doramapimod (BIRB 796); 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea; N-[2-[[4-[3-(5-tert-Butyl-2-p-tolylpyrazol-3-yl)ureido]naphthalen-1-yl]oxy]ethyl]morpholine; p38 MAP kinase inhibitor BIRB 796
EINECS	Contact for details

Quality Control

Our Doramapimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.