Description

Sodium Equilin-2,4,16,16-D4 Sulfate is a high-purity, deuterium-labeled analog of sodium equilin sulfate, a key pharmaceutical intermediate. This compound is specifically designed for use as an internal standard in advanced analytical techniques, ensuring precise quantification and method validation in complex matrices. It is primarily utilized by research institutions, pharmaceutical development laboratories, and contract research organizations (CROs) engaged in steroid hormone analysis, pharmacokinetic studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of equilin and related estrogenic compounds in biological samples (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmaceutical R&D: Used in the development and validation of analytical methods for hormone replacement therapy (HRT) products and generic drug applications.
• Metabolite Tracing: The deuterium (D4) label allows for precise tracking of drug metabolism and disposition studies in preclinical and clinical research.
• Quality Control & Assurance: Serves as a critical reference standard for in-house quality control testing of active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic & Doping Analysis: Applied in specialized testing laboratories for the detection and confirmation of steroid hormones in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Sodium Equilin-2,4,16,16-D4 Sulfate
CAS No.	285979-81-9
Molecular Formula	C18H18D4NaO4S
Molecular Weight	Contact for details
Synonyms	Equilin-2,4,16,16-d4 Sulfate Sodium Salt; Sodium 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one-2,4,16,16-d4 Sulfate; [2,4,16,16-2H4]-Equilin Sulfate Sodium Salt; Deuterated Sodium Equilin Sulfate; D4-Sodium Equilin Sulfate; Sodium Equilin-d4 Sulfate; Estra-1,3,5(10),7-tetraene-3,17-diol-2,4,16,16-d4 3-Sulfate Sodium Salt
EINECS	Contact for details

Quality Control

Our deuterium-labeled reference standards are manufactured under strict quality systems to ensure the highest levels of isotopic purity and chemical integrity. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided, detailing assay purity, isotopic enrichment, and chromatographic profile to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.