Description

Guanidine-13C, 15N Hcl is a stable isotope-labeled derivative of guanidine hydrochloride, where the carbon atom is enriched with carbon-13 and the nitrogen atoms are enriched with nitrogen-15. This isotopic labeling is critical for applications requiring precise molecular tracking and quantification, such as mass spectrometry-based proteomics and metabolic flux analysis. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require high-fidelity internal standards for accurate measurement.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analyses for the accurate determination of guanidine and related compounds in complex biological matrices.
• Metabolic Pathway Tracing: Employed in 13C and 15N isotopic labeling studies to investigate metabolic fluxes, protein turnover, and nitrogen metabolism in cell cultures and model organisms.
• Pharmaceutical Research & Development: Serves as a key labeled intermediate in the synthesis of isotopically labeled drug candidates for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Proteomics and Biomarker Discovery: Facilitates accurate protein quantification and peptide analysis in advanced proteomic workflows, including SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and related techniques.
• NMR Spectroscopy: Acts as a valuable tool in nuclear magnetic resonance (NMR) spectroscopy for structural elucidation and dynamic studies of biomolecules.
• Environmental and Food Safety Testing: Utilized in the development of highly sensitive and specific analytical methods for detecting contaminants or residues.

Basic Information

Product Name	Guanidine-13C, 15N Hcl
CAS No.	285977-73-3
Molecular Formula	CH615N3•ClH
Molecular Weight	97.53 g/mol (for 13C15N3 isotopologue)
Synonyms	Guanidine-13C,15N3 hydrochloride; Guanidine hydrochloride-13C,15N3; (Aminoiminomethyl)amine-13C,15N3 hydrochloride; Carbamidine-13C,15N3 hydrochloride; Isotopically labeled guanidine HCl; 13C,15N3-Guanidine HCl; Guanidinium-13C,15N3 chloride
EINECS	Contact for details

Quality Control

Our Guanidine-13C, 15N Hcl is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, which is paramount for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C and 15N), chemical purity, and identity confirmation. We adhere to relevant industry standards for high-purity reagents to guarantee reliable performance and traceability in your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.