Description

Barusiban is a highly selective oxytocin receptor antagonist, a synthetic peptide of significant pharmaceutical interest. Its primary value lies in its targeted mechanism of action, offering a potent and specific therapeutic effect. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing treatments in the fields of obstetrics and gynecology. Barusiban CAS NO 285571-64-4 represents a key intermediate and active pharmaceutical ingredient for advanced clinical applications.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active compound in preclinical and clinical studies for oxytocin pathway modulation.
• Obstetric Therapeutics: Primary application in the development of treatments for preterm labor, acting as a tocolytic agent to inhibit uterine contractions.
• Gynecological Formulations: Investigated for use in managing conditions related to uterine hyperactivity and dysmenorrhea.
• API Synthesis: Used as a key intermediate or the final Active Pharmaceutical Ingredient (API) in the manufacture of finished dosage forms.
• Biochemical Research: A vital tool for studying oxytocin receptor function, signaling pathways, and related physiological processes in laboratory settings.
• Veterinary Medicine: Potential applications in animal health for managing parturition-related complications in livestock.

Basic Information

Product Name	Barusiban
CAS No.	285571-64-4
Molecular Formula	C₄₃H₆₇N₁₁O₁₂S₂
Molecular Weight	994.2 g/mol
Synonyms	FE 200 440; 1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-(methylsulfanyl)propyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1H-pyrrole-2-carboxamide; (2S)-N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-(methylsulfanyl)propyl]-1H-pyrrole-2-carboxamide
EINECS	Contact for details

Quality Control

Our Barusiban is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive identification tests, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (Related Substances)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.