Description

Ac-Devd-Cmk is a specialized, high-purity chemical building block and protease inhibitor used in advanced biochemical research and pharmaceutical development. This compound is critical for studying caspase-mediated apoptotic pathways and for the synthesis of targeted therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery and proteomics applications.

Application

• Biochemical Research: As a potent and irreversible inhibitor of caspase-3 and related cysteine proteases for studying apoptosis (programmed cell death).
• Pharmaceutical Development: A key intermediate in the synthesis of novel therapeutic compounds targeting inflammatory and neurodegenerative diseases.
• Proteomics & Cell Biology: Used in enzymatic assays to elucidate specific protease functions and signaling pathways within cells.
• Diagnostic Reagent Formulation: Incorporated into kits and reagents for the detection and quantification of caspase activity.
• High-Throughput Screening (HTS): Serves as a reference standard or active component in screening libraries for drug candidate identification.

Basic Information

Product Name	Ac-Devd-Cmk
CAS No.	285570-60-7
Molecular Formula	C20H28ClN3O7S
Molecular Weight	490.97 g/mol
Synonyms	Ac-Asp-Glu-Val-Asp-CHO; Ac-DEVD-CHO; Ac-DEVD-al; Caspase-3 Inhibitor I; Ac-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-CHO; N-Acetyl-Asp-Glu-Val-Asp-al; N-Acetyl-L-aspartyl-L-α-glutamyl-N-[(1S)-3-carboxy-1-(chloromethylcarbamoyl)propyl]-L-valinamide S-oxide; Ac-DEVD-CMK (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of Ac-Devd-Cmk is manufactured and tested under strict quality management systems to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry for identity and purity verification. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.