Description

(1S,2S)-(+)-Pseudoephedrine-D3 HCl (n-Methyl-D3) is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in complex matrices. This compound is essential for ensuring data integrity and regulatory compliance in sensitive analytical workflows. It is primarily required by pharmaceutical R&D laboratories, forensic toxicology units, and contract research organizations (CROs) engaged in method development and validation for pharmacokinetic and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable, isotopically labeled reference compound for the precise quantification of pseudoephedrine and related compounds in biological samples (e.g., plasma, urine).
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetic (DMPK) studies, enabling accurate tracking of parent drug and metabolite concentrations.
• Forensic and Clinical Toxicology: Critical for developing and validating robust analytical methods to detect and quantify sympathomimetic amines in compliance with WADA and other regulatory guidelines.
• Method Development & Validation: Serves as a key reagent for establishing specificity, accuracy, and precision in new chromatographic and mass spectrometric assay protocols.
• Quality Control in API Manufacturing: Employed in analytical laboratories to monitor the synthesis and purity of active pharmaceutical ingredients (APIs) and related substances.

Basic Information

Product Name	(1S,2S)-(+)-Pseudoephedrine-D3 HCl (n-Methyl-D3)
CAS No.	284665-25-4
Molecular Formula	C10H12D3ClNO
Molecular Weight	204.73 g/mol
Synonyms	(+)-(1S,2S)-Pseudoephedrine-d3 hydrochloride; (1S,2S)-2-(Methyl-d3-amino)-1-phenylpropan-1-ol hydrochloride; Pseudoephedrine-d3 (N-methyl-d3) HCl; [2H3]-Pseudoephedrine hydrochloride; Pseudoephedrine (N-CD3) hydrochloride; (1S,2S)-Pseudoephedrine-d3 HCl; d3-Pseudoephedrine HCl
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality control protocols to ensure the highest isotopic purity and chemical integrity, which are paramount for analytical accuracy. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with every shipment to support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium, MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.