Description

Xav-939 is a potent and selective small molecule inhibitor of the Wnt/β-catenin signaling pathway, specifically targeting tankyrase 1 and 2. This compound is a critical research tool for studying cellular processes such as proliferation, differentiation, and stem cell renewal, where Wnt signaling plays a central role. It is essential for researchers and developers in the fields of oncology, regenerative medicine, and molecular biology who require high-purity biochemicals for target validation and pathway analysis.

Application

• Biomedical Research: A key reagent for investigating the molecular mechanisms of the Wnt/β-catenin signaling pathway in vitro and in vivo.
• Oncology Studies: Used to study tumorigenesis, cancer cell proliferation, and to evaluate potential therapeutic targets in various cancers, including colorectal and breast cancer.
• Stem Cell Research: Employed to modulate Wnt signaling to control stem cell self-renewal, differentiation, and pluripotency.
• Drug Discovery & Development: Serves as a pharmacological probe and reference standard in high-throughput screening and lead optimization for novel tankyrase inhibitors.
• Academic & Institutional Laboratories: Fundamental tool for basic research in developmental biology, tissue homeostasis, and disease modeling.

Basic Information

Product Name	Xav-939
CAS No.	284028-89-3
Molecular Formula	C₁₉H₁₄N₂O₄
Molecular Weight	334.33 g/mol
Synonyms	XAV939; XAV 939; 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one; Tankyrase Inhibitor I; WIKI4; NSC 207895
EINECS	Contact for details

Quality Control

Our Xav-939 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry for identity confirmation and purity assessment. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.