Description

n-Smase Spiroepoxide Inhibitor is a specialized small molecule compound designed to selectively inhibit neutral sphingomyelinase (n-SMase) activity. This targeted inhibition is crucial for modulating ceramide-mediated signaling pathways involved in cellular stress responses and apoptosis. It serves as a vital research tool for scientists in the fields of biochemistry, cell biology, and pharmacology, particularly for investigating the role of sphingolipid metabolism in disease models and potential therapeutic interventions.

Application

• Biochemical Research: A key reagent for studying the enzymatic activity and biological function of neutral sphingomyelinase in vitro and in cell-based assays.
• Cell Signaling Studies: Used to investigate the downstream effects of ceramide generation on apoptosis, inflammation, and cellular senescence pathways.
• Neuroscience Research: Applied in models of neurological disorders where sphingolipid imbalance is implicated, such as Alzheimer's disease and multiple sclerosis.
• Drug Discovery: Serves as a pharmacological tool and a lead compound scaffold for developing novel therapeutics targeting sphingomyelinase-related diseases.
• Academic & Pharmaceutical R&D: Essential for basic research and pre-clinical development in universities, research institutes, and biopharmaceutical companies.

Basic Information

Product Name	n-Smase Spiroepoxide Inhibitor
CAS No.	282108-77-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GW4869; nSMase Inhibitor; Neutral Sphingomyelinase Inhibitor; Dihydrochloride Salt of GW4869; 2,2'-[Hexan-1,6-diylbis[(3,3-diphenylpropyl)azanediyl]]diethanol; Spiroepoxide-based n-SMase Inhibitor; Ceramide Pathway Inhibitor
EINECS	Contact for details

Quality Control

Our n-Smase Spiroepoxide Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including purity assay and identity confirmation, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the product meets the high standards required for scientific investigation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.