Description

Gw 4064 CAS NO 278779-30-9 is a high-purity, small molecule chemical compound of significant interest in pharmaceutical and life science research. This compound serves as a potent and selective agonist for the farnesoid X receptor (FXR), a key nuclear receptor involved in regulating bile acid, lipid, and glucose metabolism. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors. Its application is critical for investigating metabolic pathways and developing novel therapeutics for conditions such as liver disease, diabetes, and dyslipidemia.

Application

• Pharmaceutical Research & Development: As a reference standard and active tool compound for studying FXR-mediated biological pathways.
• Metabolic Disease Studies: Used in in vitro and in vivo models to explore treatments for non-alcoholic steatohepatitis (NASH), primary biliary cholangitis (PBC), and type 2 diabetes.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to identify and characterize new FXR modulators.
• Academic Research: A key reagent for universities and research institutes focusing on nuclear receptor biology and metabolic regulation.
• Preclinical Drug Development: Serves as a benchmark compound for efficacy and pharmacokinetic studies in animal models.

Basic Information

Product Name	Gw 4064 CAS NO 278779-30-9
CAS No.	278779-30-9
Molecular Formula	C26H23Cl2NO4S
Molecular Weight	516.44 g/mol
Synonyms	GW4064; GW-4064; 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic Acid; Fexaramine; FXR Agonist GW4064; GSK 4064; 6-ECDCA; 6α-Ethyl-chenodeoxycholic Acid (analog); Bile Acid Receptor Agonist
EINECS	Contact for details

Quality Control

Our Gw 4064 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.