Description

Philanthotoxin 433 Tris-Trifluoroacetate is a high-purity, polyamine-containing neurotoxin analog, specifically isolated and purified to a level exceeding 99%. This compound is a critical research tool for studying ionotropic glutamate receptors, particularly AMPA and kainate subtypes, due to its potent non-competitive antagonistic activity. It is essential for neuroscientists, pharmacologists, and biochemists engaged in neurological research, drug discovery for CNS disorders, and the study of synaptic transmission mechanisms.

Application

• Neuroscience Research: A key pharmacological tool for the selective blockade of non-NMDA glutamate receptors (AMPA/kainate receptors) in electrophysiology and neuropharmacology studies.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays and target validation for neurological conditions such as epilepsy, stroke, and neurodegenerative diseases.
• Cellular & Molecular Biology: Employed to investigate the role of glutamatergic signaling in synaptic plasticity, neuronal excitotoxicity, and cell death pathways.
• Biochemical Assays: Serves as a reference standard and active agent in receptor binding studies and functional characterization of ion channel modulators.
• Toxicology Studies: Used to model and understand the mechanisms of natural neurotoxins and to develop potential therapeutic counteragents.

Basic Information

Item	Details
Product Name	Philanthotoxin 433 Tris-Trifluoroacetate
CAS No.	276684-27-6
Molecular Formula	C₂₃H₄₀N₈O₇ • xC₂HF₃O₂
Molecular Weight	Contact for details
Synonyms	PhTX-433; Philanthotoxin-433; Philanthotoxin 433; N-[(2S)-5-[[(2S)-5-[[(2S)-2-Amino-5-guanidinopentyl]amino]pentyl]amino]pentyl]-2-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]acetamide Tris(trifluoroacetate); AR-R 18556; Glutamate receptor antagonist PhTX-433
EINECS	Contact for details

Quality Control

Every batch of Philanthotoxin 433 Tris-Trifluoroacetate is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our >99% purity grade is verified by multiple orthogonal analytical methods, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with each shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a desiccated environment. Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	> 99.0%
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.