Description

(4R)-Monastrol CAS NO 268739-54-4 is a specific enantiomer of the small molecule kinesin Eg5 inhibitor, Monastrol. This compound is of significant value in biochemical and pharmacological research as a selective, cell-permeable tool for studying mitosis and spindle assembly dynamics. It is primarily required by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cell biology, cancer research, and the development of novel anti-mitotic therapeutics.

Application

• Biochemical Research Tool: Used as a specific inhibitor of the mitotic kinesin Eg5 to study spindle pole separation and mitotic checkpoint mechanisms.
• Cell Biology Studies: Employed in live-cell imaging and functional assays to investigate the dynamics of cell division and mitotic arrest.
• Cancer Research: Serves as a lead compound or reference standard in the discovery and validation of novel anti-cancer agents targeting the mitotic machinery.
• Mechanism of Action (MoA) Studies: Utilized to elucidate the pathways and phenotypic consequences of Eg5 inhibition in various cell lines.
• High-Content Screening (HCS): Acts as a positive control or validation compound in screening campaigns for modulators of mitosis.
• Enantioselective Pharmacology: Provides the (4R)-enantiomer for studies comparing the biological activity and selectivity of Monastrol stereoisomers.

Basic Information

Product Name	(4R)-Monastrol
CAS No.	268739-54-4
Molecular Formula	C₁₄H₁₄N₂O₃S
Molecular Weight	290.34 g/mol
Synonyms	(4R)-2-(3-Hydroxyphenyl)-5,6,7,8-tetrahydro-4H-thiochromen-4-one 3,4-dihydro-2(1H)-pyrimidinone; (R)-Monastrol; (4R)-Monastrol; (R)-2-(3-Hydroxyphenyl)-5,6,7,8-tetrahydro-4H-thiochromen-4-one 3,4-dihydro-2(1H)-pyrimidinone; Eg5 Inhibitor (R)-enantiomer; (R)-Hexahydro-2-(3-hydroxyphenyl)-8-thioxo-4H,8H-pyrimido[2,1-b][1,3]thiazin-4-one
EINECS	Contact for details

Quality Control

Our (4R)-Monastrol is produced under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and optical rotation measurement to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.