Description

Repertaxin CAS NO 266359-83-5 is a potent and selective small-molecule inhibitor of the chemokine receptor CXCR1/2, which plays a critical role in inflammatory signaling pathways. This compound is of significant value for research and development in the pharmaceutical and biotechnology sectors, particularly for investigating novel anti-inflammatory and anti-cancer therapeutics. It is primarily needed by research scientists, process development chemists, and manufacturers in the fields of immunology, oncology, and drug discovery.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of CXCR1/2-targeted drugs.
• Inflammation Studies: Used in in vitro and in vivo models to study neutrophil migration, acute lung injury, arthritis, and other inflammatory diseases.
• Oncology Research: Investigated for its potential to inhibit tumor growth and metastasis by blocking CXCR2-mediated signaling in the tumor microenvironment.
• Biochemical Assay Development: Serves as a critical tool compound for high-throughput screening (HTS) and validating assays targeting chemokine receptors.
• Process Chemistry: Utilized as a building block or intermediate in the scalable synthesis of more complex therapeutic candidates.

Basic Information

Product Name	Repertaxin
CAS No.	266359-83-5
Molecular Formula	C₁₉H₂₁N₃O₄
Molecular Weight	355.39 g/mol
Synonyms	Repertaxin; (R)-2-(4-Isobutylphenyl)propionyl Methanesulfonamide; DF 2156A; (R)-2-(4-(2-Methylpropyl)phenyl)propanoic acid methanesulfonamide; CXCR1/2 Inhibitor I; NSC 759836; (R)-2-(4-Isobutylphenyl)propionic acid methanesulfonamide; (R)-2-(p-Isobutylphenyl)propionyl methanesulfonamide
EINECS	Contact for details

Quality Control

Our Repertaxin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.