Description

Telomestatin is a potent and highly specific natural product inhibitor of telomerase, an enzyme critical for cancer cell immortality. This compound matters for its role as a key research tool in oncology, biochemistry, and molecular biology, enabling the study of telomere maintenance mechanisms and potential anti-cancer strategies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer therapeutics and aging research.

Application

• Biochemical Research: Used as a specific telomerase inhibitor to study telomere biology, cellular senescence, and immortalization pathways.
• Oncology & Cancer Drug Discovery: Serves as a reference compound and lead structure in the development of novel anti-cancer therapeutics targeting telomerase activity.
• Molecular Biology Studies: Employed in assays to investigate the role of telomerase in cell proliferation, aging, and genomic stability.
• Academic & Pharmaceutical R&D: A critical reagent for high-throughput screening (HTS) campaigns and mechanistic studies in life science research.
• Standards & Controls: Used as a certified reference material (CRM) or analytical standard for quality control in related research applications.

Basic Information

Product Name	Telomestatin
CAS No.	265114-54-3
Molecular Formula	C57H92N12O18
Molecular Weight	1161.4 g/mol
Synonyms	Telomestatin; Telomestatin (Telomerase Inhibitor); LKKTALL; Telomestatin, Streptomyces anulatus; Telomestatin (Telomere Inhibitor); Telomestatin (Telomerase Blocker); Telomestatin (Telomere/Telomerase Inhibitor); Telomestatin (Telomerase/Telomere Inhibitor)
EINECS	Contact for details

Quality Control

Our Telomestatin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification. A detailed Certificate of Analysis (COA), providing full analytical data and specifications, is supplied with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Biological Activity (Telomerase Inhibition)	IC50 ≤ 5 nM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.