Description

2-Chloro-5-Chlorosulfonyl-4-Fluorobenzoic Acid is a high-purity, multi-functional chemical intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both a chlorosulfonyl and a carboxylic acid group on a fluorinated benzene ring, makes it a versatile building block for creating complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, metabolic disorders, and infectious diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorosulfonyl groups contribute to biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments with specific light-fastness and color properties.
• Cross-Coupling Reactions: The halogenated aromatic ring makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct biaryl systems.
• Sulfonamide Derivative Production: The reactive chlorosulfonyl group is readily converted into a variety of sulfonamides, which are important pharmacophores in medicinal chemistry.

Basic Information

Product Name	2-Chloro-5-Chlorosulfonyl-4-Fluorobenzoic Acid
CAS No.	264927-50-6
Molecular Formula	C7H3Cl2FO4S
Molecular Weight	273.07 g/mol
Synonyms	4-Fluoro-2-chloro-5-(chlorosulfonyl)benzoic acid; 2-Chloro-4-fluoro-5-sulfonylchloride benzoic acid; Benzoic acid, 2-chloro-5-(chlorosulfonyl)-4-fluoro-; 5-Chlorosulfonyl-2-chloro-4-fluorobenzoic acid; 264927-50-6; 2-Chloro-4-fluoro-5-chlorosulfonylbenzoic acid
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this intermediate, ensuring batch-to-batch consistency and high purity suitable for sensitive synthesis applications. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and related substances. We can support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.