Description

Apigenin-D5 CAS NO 263711-74-6 is a deuterium-labeled analog of the naturally occurring flavonoid apigenin, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is an essential internal standard for the precise quantification of apigenin in complex biological matrices using mass spectrometry. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and life science sectors requiring high-accuracy analytical data.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a quantitative reference standard in pharmacokinetic and bioavailability studies of apigenin and its derivatives.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of apigenin absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Nutraceutical and Herbal Extract Analysis: Used to assay apigenin content in dietary supplements, functional foods, and botanical extracts for quality control and label claim verification.
• Biomarker Research: Facilitates the measurement of apigenin as a dietary biomarker in epidemiological and nutritional intervention studies.
• Method Development and Validation: Serves as a critical component in developing and validating robust analytical methods in compliance with ICH and FDA guidelines.
• Stable Isotope Dilution Assays: Provides the highest accuracy in quantitative analyses by correcting for analyte loss during sample preparation and ionization suppression in mass spectrometers.

Basic Information

Item	Detail
Product Name	Apigenin-D5
CAS No.	263711-74-6
Molecular Formula	C15H5D5O5
Molecular Weight	275.28 g/mol
Synonyms	4',5,7-Trihydroxyflavone-d5; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5; Apigenin (phenyl-d5); Apigenin-d5 (Deuterated Apigenin); [2H5]-Apigenin; Apigenin Internal Standard; Stable Isotope-Labeled Apigenin
EINECS	Contact for details

Quality Control

Every batch of Apigenin-D5 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (typically >98 atom % D), chemical purity (by HPLC), and confirmation of structure. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference material in regulated analytical environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.