Description

γ-Secretase Inhibitor II is a potent and selective small molecule inhibitor of the γ-secretase enzyme complex. This compound is a critical research tool for investigating the Notch signaling pathway and its role in cellular differentiation, development, and disease progression. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, oncology, and regenerative medicine studies.

Application

• Notch Signaling Pathway Research: Fundamental tool for studying the biological functions and inhibition mechanisms of γ-secretase.
• Alzheimer's Disease Research: Used in models investigating amyloid-beta (Aβ) peptide production and potential therapeutic interventions.
• Cancer Biology Studies: Applied in research targeting Notch-dependent tumor growth, angiogenesis, and cancer stem cells.
• Cell Differentiation & Development: Essential for experiments exploring the role of Notch in cell fate decisions and tissue development.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in drug discovery campaigns targeting γ-secretase.
• Biochemical Assay Development: Used to validate and optimize in vitro enzymatic assays for γ-secretase activity.

Basic Information

Product Name	γ-Secretase Inhibitor II
CAS No.	263563-09-3
Molecular Formula	C₂₀H₂₅N₃O₄
Molecular Weight	371.43 g/mol
Synonyms	DAPT; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; LY-374973; GSI-IX; γ-Secretase Inhibitor IX; (S)-N-(3,5-Difluorophenacetyl)alanyl-2-phenylglycine-1,1-dimethylethyl ester; N2-[(2S)-2-[(1,1-Dimethylethoxy)carbonylamino]-1-oxopropyl]-N1-(3,5-difluorophenyl)-2-oxo-1-pyrrolidineacetamide
EINECS	Contact for details

Quality Control

Our γ-Secretase Inhibitor II is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and structural verification by NMR and mass spectrometry, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.