Description

Barixibat is a potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT), designed to modulate bile acid reabsorption in the ileum. This mechanism of action makes it a critical compound for research and development in the treatment of chronic cholestatic liver diseases and related metabolic disorders. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on hepatology and gastroenterology.

Application

• Pharmaceutical research and development for cholestatic liver diseases (e.g., Primary Biliary Cholangitis, Alagille Syndrome).
• Investigational studies targeting pruritus (itching) associated with chronic liver conditions.
• Preclinical and clinical development of novel metabolic disorder therapeutics.
• Biochemical research on bile acid metabolism and enterohepatic circulation pathways.
• Reference standard for analytical method development and quality control in API manufacturing.
• Pharmacology studies to understand ASBT inhibition and its systemic effects.

Basic Information

Product Name	Barixibat
CAS No.	263562-28-3
Molecular Formula	C29H41N3O6S
Molecular Weight	559.72 g/mol
Synonyms	1-[4-[[4-[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]methyl]phenyl]cyclopentanecarboxylic acid; SD-5613; A-3309; Barixibat sodium; GSK-2330672; ASBT Inhibitor
EINECS	Contact for details

Quality Control

Our Barixibat CAS NO 263562-28-3 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.