Description

Tetrahydropyran-4-Ylmagnesium Chloride, 0.50 M In Thf CAS NO 263257-15-4 is a versatile organometallic reagent supplied as a standardized 0.50 M solution in tetrahydrofuran (THF). This compound is a critical building block for introducing the tetrahydropyran-4-yl moiety, a valuable structural motif in medicinal chemistry and advanced material synthesis. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to streamline complex molecule construction through efficient Grignard chemistry.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing complex drug molecules, particularly those containing chiral tetrahydropyran rings found in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the tetrahydropyran structure enhances biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel polymers and advanced organic materials with tailored properties.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed cross-coupling reactions (e.g., Kumada coupling) for carbon-carbon bond formation.
• Nucleophilic Addition to Carbonyls: Standard application for adding the tetrahydropyran-4-yl group to aldehydes, ketones, and esters.

Basic Information

Item	Details
Product Name	Tetrahydropyran-4-Ylmagnesium Chloride, 0.50 M In Thf
CAS No.	263257-15-4
Molecular Formula	C5H9ClMgO
Molecular Weight	144.88 g/mol
Synonyms	4-Magnesiotetrahydropyran Chloride; THP-4-MgCl; Tetrahydropyran-4-ylmagnesium Chloride solution; 4-(Chloromagnesio)tetrahydropyran; Magnesium, chloro(4-tetrahydro-2H-pyranyl)-; (Tetrahydropyran-4-yl)magnesium chloride; Grignard Reagent from 4-Chlorotetrahydropyran
EINECS	Contact for details

Quality Control

Every batch of our Tetrahydropyran-4-Ylmagnesium Chloride solution is manufactured and tested under strict quality management systems. We ensure precise molarity, high reactivity, and minimal impurities through rigorous analytical protocols, including titration and GC analysis. Certificates of Analysis (COA) detailing concentration, identity, and purity are provided with each shipment to guarantee consistency and support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. Due to its highly volatile and moisture-sensitive nature, the solution must be handled under anhydrous conditions using standard Schlenk or glovebox techniques to prevent decomposition and ensure optimal performance.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.50 M in THF
Identification (IR)	Conforms to structure
Assay (Titration)	0.48 - 0.52 M
Water Content (Karl Fischer)	< 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.