Description

Didesmethyl (αr)-Sibutramine Hydrochloride is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for research and development in the field of metabolic studies and analytical method validation. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories requiring precise and reliable materials for their processes.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and the validation of testing methods in quality control laboratories.
• Metabolic Research: Serves as a key intermediate or biomarker in studies investigating drug metabolism pathways and pharmacokinetics.
• Impurity Profiling: Employed as a certified impurity standard to identify and quantify related substances in active pharmaceutical ingredient (API) batches.
• Method Development: Essential for developing and optimizing chromatographic (HPLC, LC-MS) and spectroscopic analytical procedures.
• Regulatory Submissions: Provides necessary data and materials for regulatory filings and compliance documentation with agencies like the FDA and EMA.

Basic Information

Item	Detail
Product Name	Didesmethyl (αr)-Sibutramine Hydrochloride
CAS No.	262854-35-3
Molecular Formula	C15H22ClN
Molecular Weight	251.80 g/mol
Synonyms	Didesmethylsibutramine HCl; (αr)-Didesmethylsibutramine Hydrochloride; 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine Hydrochloride; Sibutramine Impurity F (Hydrochloride); Ar-Didesmethyl Sibutramine HCl; DDSB HCl; 262854-35-3
EINECS	Contact for details

Quality Control

Our Didesmethyl (αr)-Sibutramine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.