Description

4-Fluoro-3-Methylbenzyl Bromide is a versatile and high-purity benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of the bromomethyl group and fluorine substituent, enabling efficient functionalization and the introduction of fluorinated motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other bioactive molecules where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom to improve pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Material Production: Acts as a fluorinated building block for creating advanced organic electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Functional Polymer Modification: Employed to introduce fluorinated benzyl groups into polymer backbones, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: Serves as a competent electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl and conjugated systems.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Fluoro-3-Methylbenzyl Bromide
CAS No.	261951-70-6
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-(Bromomethyl)-4-fluoro-3-methylbenzene; (4-Fluoro-3-methylphenyl)methyl bromide; 3-Methyl-4-fluorobenzyl bromide; α-Bromo-4-fluoro-3-methyltoluene; 4-Fluoro-m-tolylmethyl bromide; 4-Fluoro-3-methylbenzylbromide; 4-Fluoro-3-methyl-benzylbromide
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methylbenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most sensitive synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.