Description

1-Bromo-2,5-Difluoro-4-(Trifluoromethyl)Benzene is a high-value, multi-halogenated aromatic building block designed for advanced synthetic chemistry. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group, makes it an essential intermediate for introducing specific substitution patterns into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups improve biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique characteristics such as chemical resistance, thermal stability, and specific optical properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl and conjugated systems.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial research focused on exploring new fluorination methodologies and the effects of fluorine substitution on molecular behavior.

Basic Information

Product Name	1-Bromo-2,5-Difluoro-4-(Trifluoromethyl)Benzene
CAS No.	261945-75-9
Molecular Formula	C7H2BrF5
Molecular Weight	260.99 g/mol
Synonyms	2,5-Difluoro-4-(trifluoromethyl)bromobenzene; 4-Bromo-2,5-difluorobenzotrifluoride; 1-Bromo-2,5-difluoro-4-(trifluoromethyl)benzene; Benzene, 1-bromo-2,5-difluoro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2,5-difluorobromobenzene; 2,5-Difluoro-α,α,α-trifluoro-4-bromotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,5-Difluoro-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reducing agents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.8 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.