Description

2,3-Difluoro-4-Methylbenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the 2,3-difluoro-4-methylbenzoyl moiety. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals. Its specific substitution pattern offers unique steric and electronic properties for modulating the biological activity and physicochemical characteristics of target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluoromethylbenzoyl group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, improving charge transport and thermal stability.
• Polymer Chemistry: Acts as a monomer or modifying agent for introducing fluorinated aromatic units into high-performance polymers and coatings.
• Chemical Research & Development: Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments with enhanced lightfastness and color properties.

Basic Information

Product Name	2,3-Difluoro-4-Methylbenzoyl Chloride
CAS No.	261763-38-6
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	4-Methyl-2,3-difluorobenzoyl chloride; 2,3-Difluoro-4-methylbenzoic acid chloride; 2,3-Difluoro-p-toluoyl chloride; 2,3-Difluoro-4-toluoyl chloride; 261763-38-6; 4-Methyl-2,3-difluorobenzoic acid chloride; Benzoic acid, 2,3-difluoro-4-methyl-, chloride
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Methylbenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request. We adhere to cGMP principles where applicable to support our customers in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.