Description

5-Cyano-2-Fluoro-3-Picoline is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both cyano and fluoro substituents on the pyridine ring, makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific fluorinated aromatic units.
• Chemical Biology Probes: Useful for incorporating fluorinated tags and reporter groups into biomolecules for study.

Basic Information

Product Name	5-Cyano-2-Fluoro-3-Picoline
CAS No.	261625-67-6
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	2-Fluoro-5-cyano-3-picoline; 3-Methyl-2-fluoro-5-cyanopyridine; 5-Cyano-2-fluoro-3-methylpyridine; 2-Fluoro-3-methyl-5-cyanopyridine; 3-Picoline, 5-cyano-2-fluoro-; 261625-67-6; 5-Cyano-2-fluoro-3-methylpyridine
EINECS	Contact for details

Quality Control

Our 5-Cyano-2-Fluoro-3-Picoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.