Description

2-Chloro-5-Iodobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira), while the chlorine allows for sequential functionalization.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and molecular recognition studies.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Chloro-5-Iodobenzotrifluoride
CAS No.	260355-20-2
Molecular Formula	C7H3ClF3I
Molecular Weight	305.45 g/mol
Synonyms	1-Chloro-4-iodo-2-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-5-iodotoluene; 2-Chloro-5-iodobenzotrifluoride; 2-Chloro-5-iodo-α,α,α-trifluorotoluene; 5-Iodo-2-chlorobenzotrifluoride; Benzene, 1-chloro-4-iodo-2-(trifluoromethyl)-; 2-Chloro-5-iodo-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.