Description

2-Nitro-4-Iodo-5-Fluorotoluene is a high-purity halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring nitro, iodo, and fluoro substituents on a toluene backbone, makes it a versatile precursor for constructing complex molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those targeting specific enzyme inhibition or receptor modulation.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of advanced organic electronic materials, such as organic semiconductors and liquid crystals.
• Dye & Pigment Synthesis: Acts as a precursor for creating specialized dyes and pigments with unique colorfastness and light-absorption properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups allow for selective substitution, enabling the introduction of various nucleophiles.

Basic Information

Product Name	2-Nitro-4-Iodo-5-Fluorotoluene
CAS No.	259860-34-9
Molecular Formula	C7H5FINO2
Molecular Weight	281.03 g/mol
Synonyms	1-Fluoro-2-methyl-4-iodo-5-nitrobenzene; 5-Fluoro-2-methyl-1-iodo-4-nitrobenzene; 2-Methyl-4-iodo-5-fluoronitrobenzene; 4-Iodo-5-fluoro-2-nitrotoluene; Toluene, 2-nitro-4-iodo-5-fluoro-; 259860-34-9; 2-Nitro-4-iodo-5-fluoromethylbenzene
EINECS	Contact for details

Quality Control

Our 2-Nitro-4-Iodo-5-Fluorotoluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.