Description

Trpm8 Antagonist CAS NO 259674-19-6 is a potent and selective small-molecule inhibitor of the Transient Receptor Potential Melastatin 8 (TRPM8) ion channel, a key cold and menthol sensor. This compound is a critical research tool for elucidating the role of TRPM8 in thermosensation, pain pathways, and various associated physiological and pathological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and urology.

Application

• Neuroscience Research: Used as a pharmacological probe to study the role of TRPM8 channels in cold sensation, thermoregulation, and neuropathic pain models.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel analgesic and antipruritic (anti-itch) therapeutics targeting chronic pain and cold allodynia.
• Urological Research: Investigated for its potential effects on bladder function and conditions such as overactive bladder syndrome, where TRPM8 is implicated.
• In Vitro & In Vivo Studies: Essential for functional assays, including calcium imaging and electrophysiology, to characterize TRPM8 channel activity and inhibition.
• Mechanistic Biology: Helps in understanding downstream signaling pathways activated by TRPM8 in various cell types and disease states.

Basic Information

Product Name	Trpm8 Antagonist
CAS No.	259674-19-6
Molecular Formula	C₁₉H₂₁N₃O₃
Molecular Weight	339.39 g/mol
Synonyms	N-(4-tert-Butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide; AMG 2850; AMG-2850; TRPM8 Antagonist; TRPM8 Blocker; Cold Receptor Antagonist; (4-tert-Butylphenyl)-[4-(3-chloropyridin-2-yl)piperazin-1-yl]methanone (common alternate representation)
EINECS	Contact for details

Quality Control

Our Trpm8 Antagonist is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The compound is hygroscopic and should be handled under inert atmosphere or in a desiccator to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.