Description

4-Fluoromethylpiperidine is a high-value fluorinated piperidine derivative, a versatile building block prized for its role in advanced organic synthesis. Its unique structure, featuring a fluoromethyl substituent on the piperidine ring, makes it a critical intermediate for modulating the physicochemical and pharmacokinetic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning candidate compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of novel fluorinated polymers and specialty chemicals with unique surface properties.
• Chemical Biology Probes: Utilized to introduce fluorine tags into molecules for studies using techniques like 19F NMR spectroscopy.

Basic Information

Product Name	4-Fluoromethylpiperidine
CAS No.	259143-04-9
Molecular Formula	C6H12FN
Molecular Weight	117.16 g/mol
Synonyms	4-(Fluoromethyl)piperidine; 4-Fluoromethyl-piperidine; Piperidine, 4-(fluoromethyl)-; 4-Fluoromethylpiperidine; 4-(Fluoromethyl)piperidine hydrochloride (salt form); 1-Boc-4-(fluoromethyl)piperidine (protected form); 4-Fluoromethyl-piperidine, HCl; 259143-04-9
EINECS	Contact for details

Quality Control

Our 4-Fluoromethylpiperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles to meet your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.