Description

(3S,5S)-3,5-Difluoropiperidine Hydrochloride is a high-purity, chiral fluorinated piperidine derivative supplied as a hydrochloride salt. This compound serves as a critical chiral building block and intermediate in modern pharmaceutical research and development, particularly for the synthesis of complex active pharmaceutical ingredients (APIs). It is essential for medicinal chemists and process development scientists working in drug discovery for central nervous system (CNS) disorders, oncology, and metabolic diseases, where its defined stereochemistry and fluorine atoms are leveraged to modulate potency, selectivity, and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting protease enzymes and G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms and a rigid piperidine scaffold to optimize pharmacokinetic and pharmacodynamic properties.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for advanced intermediates under current Good Manufacturing Practice (cGMP) standards.
• Agrochemical Synthesis: Potential intermediate for developing new generation pesticides and herbicides that require fluorinated, stereochemically defined heterocycles.
• Ligand & Catalyst Development: Can be utilized in the preparation of chiral ligands for asymmetric catalysis or as a component in organocatalysts.

Basic Information

Product Name	(3S,5S)-3,5-Difluoropiperidine Hydrochloride
CAS No.	259110-61-7
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	(3S,5S)-3,5-Difluoropiperidine HCl; (3S,5S)-3,5-Difluoropiperidinium Chloride; 3,5-Difluoropiperidine Hydrochloride, (3S,5S)-; 3,5-Difluoro-3,5-piperidine Hydrochloride; (3S,5S)-3,5-Difluoropiperidine Hydrochloride Salt; 259110-61-7; (3S-cis)-3,5-Difluoropiperidine Hydrochloride
EINECS	Contact for details

Quality Control

Our (3S,5S)-3,5-Difluoropiperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.