Description

(3S,5R)-3,5-Difluoropiperidine Hydrochloride is a high-purity, chiral fluorinated piperidine derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in its ability to introduce both fluorine atoms and a constrained piperidine scaffold, which are key motifs for modulating the potency, metabolic stability, and bioavailability of drug candidates. This advanced intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, particularly for the development of new active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for CNS-targeting drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the difluoropiperidine structure confers specific biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorination on drug-like properties.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability against enzymatic degradation.
• Fluorine Chemistry Library Building: A valuable component for constructing diverse compound libraries focused on fluorine-containing molecules for high-throughput screening.

Basic Information

Product Name	(3S,5R)-3,5-Difluoropiperidine Hydrochloride
CAS No.	259110-60-6
Molecular Formula	C5H10F2N·HCl
Molecular Weight	155.60 (Free base) / 192.06 (HCl salt)
Synonyms	(3S,5R)-3,5-Difluoropiperidine HCl; (3S,5R)-3,5-Difluoropiperidine hydrochloride; 3,5-Difluoropiperidine hydrochloride, (3S,5R)-; (3S,5R)-3,5-Difluoropiperidinium chloride; (3S-cis)-3,5-Difluoropiperidine hydrochloride; 3,5-Difluoropiperidine HCl (cis isomer); Piperidine, 3,5-difluoro-, hydrochloride, (3S,5R)-; 259110-60-6
EINECS	Contact for details

Quality Control

Our (3S,5R)-3,5-Difluoropiperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity, chemical identity, and conformity to specified limits for impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from tests such as HPLC for assay and enantiomeric excess, NMR, and residual solvent analysis. Our quality commitment supports cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.