Description

(S)-4-Ethyl-4-Hydroxy-11-[2-(Isopropylamino)Ethyl]-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14-Dione is a complex, chiral alkaloid derivative with a fused polycyclic structure, representing a high-value synthetic intermediate in advanced pharmaceutical research. This compound matters for its role as a key building block in the synthesis of potent, targeted therapeutic agents, particularly in oncology and other specialized medicinal chemistry applications. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to develop novel drug candidates and conduct critical structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel anticancer and antitumor agents.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in pharmacological studies to investigate specific biological pathways and enzyme interactions.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Asymmetric Synthesis: Acts as a chiral template or building block for the construction of complex, enantiomerically pure molecules.
• Academic & Contract Research: Fundamental research in organic chemistry and pharmacology within university and CRO (Contract Research Organization) settings.

Basic Information

Product Name	(S)-4-Ethyl-4-Hydroxy-11-[2-(Isopropylamino)Ethyl]-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14-Dione
CAS No.	256411-32-2
Molecular Formula	C₂₇H₃₁N₃O₄
Molecular Weight	461.56 g/mol
Synonyms	(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; (S)-Homocamptothecin derivative; (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Topoisomerase I inhibitor intermediate; S-HCPT analog; 256411-32-2; (S)-4-Ethyl-4-hydroxy-11-[2-(propan-2-ylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
EINECS	Contact for details

Quality Control

Our (S)-4-Ethyl-4-Hydroxy-11-[2-(Isopropylamino)Ethyl]-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% to ≥98% by HPLC), chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.