Description

Bay 41-2272 is a potent and selective soluble guanylyl cyclase (sGC) stimulator, a key compound in cardiovascular and pulmonary research. This high-purity chemical reference standard is essential for investigating nitric oxide-independent pathways and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on hypertension, pulmonary arterial hypertension (PAH), and other vascular disorders.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of new cardiovascular drugs.
• Mechanistic Studies: Used extensively in vitro and in vivo to study the role of soluble guanylyl cyclase (sGC) in vasodilation, platelet aggregation, and cellular signaling pathways.
• Preclinical Development: Employed in animal models to evaluate efficacy and pharmacokinetics for potential treatments targeting pulmonary arterial hypertension (PAH) and systemic hypertension.
• Biochemical Assays: Acts as a key tool compound in high-throughput screening (HTS) and enzyme activity assays to identify and characterize new sGC modulators.
• Academic Research: Supports fundamental research in universities and institutes exploring vascular biology, smooth muscle function, and cGMP-mediated processes.

Basic Information

Product Name	Bay 41-2272
CAS No.	256376-24-6
Molecular Formula	C20H21N5O3
Molecular Weight	379.42 g/mol
Synonyms	5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine; BAY 41-2272; BAY-41-2272; BAY412272; 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(cyclopropyl)-4-pyrimidinamine; sGC Stimulator Bay 41-2272
EINECS	Contact for details

Quality Control

Every batch of Bay 41-2272 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) confirming identity, purity, and consistency. Our quality protocols are designed to meet the stringent requirements of pharmaceutical research and development, ensuring reliable and reproducible results for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.