Description

Geldanamycin, 17-Demethoxy-17-[[3-[[4-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-1-Oxobutyl]Amino]Propyl]Amino]- is a chemically modified derivative of the natural ansamycin antibiotic, geldanamycin, designed for enhanced research utility. This compound matters as a critical biochemical tool for studying heat shock protein 90 (Hsp90) inhibition and its role in cellular processes. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative disease, and protein folding research.

Application

• Biochemical Research: A key reagent for investigating Hsp90-client protein interactions and chaperone function in vitro.
• Anticancer Mechanism Studies: Used to study the inhibition of Hsp90 in cancer cell lines, exploring pathways for tumor growth suppression.
• Proteostasis Research: Applied in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) to understand protein misfolding and aggregation.
• Chemical Biology Probe Development: Serves as a precursor or reference compound for developing novel Hsp90-targeted probes and conjugates.
• High-Throughput Screening (HTS): Utilized as a control or standard compound in assays designed to discover new Hsp90 inhibitors.
• Structure-Activity Relationship (SAR) Studies: Provides a core structure for medicinal chemistry programs aimed at optimizing drug-like properties.

Basic Information

Product Name	Geldanamycin, 17-Demethoxy-17-[[3-[[4-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-1-Oxobutyl]Amino]Propyl]Amino]-
CAS No.	256337-10-7
Molecular Formula	C36H47N5O9
Molecular Weight	693.80 g/mol
Synonyms	17-Demethoxy-17-[[3-[[4-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-1-Oxobutyl]Amino]Propyl]Amino]geldanamycin; Geldanamycin, 17-demethoxy-17-[[3-[[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutyl]amino]propyl]amino]-; 17-DMAPG; Maleimide-geldanamycin derivative; Hsp90 Inhibitor Derivative; Ansamycin Derivative; 17-(3-((4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl)amino)propylamino)-17-demethoxygeldanamycin
EINECS	Contact for details

Quality Control

Our Geldanamycin derivative is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is moisture-sensitive; keep the container tightly sealed in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.