Description

Monastrol is a potent and selective small molecule inhibitor of the mitotic kinesin Eg5, a key protein involved in spindle assembly during cell division. This targeted mechanism makes it a valuable chemical tool for disrupting mitosis and inducing cell cycle arrest, primarily in cancer research. It is extensively utilized in biochemical and pharmacological studies to investigate mitotic mechanisms, validate drug targets, and screen for novel anti-cancer therapeutics. Researchers in pharmaceutical R&D, academic institutions, and biotechnology firms rely on high-purity Monastrol for its consistent biological activity and reliability in experimental models.

Application

• Biochemical Research: A critical tool for studying the function of the kinesin Eg5 and the dynamics of mitotic spindle formation.
• Anticancer Drug Discovery: Used in high-throughput screening assays to identify and evaluate new compounds targeting the mitotic machinery.
• Cell Biology Studies: Employed to induce monopolar spindles and arrest cells in mitosis, facilitating research into cell cycle checkpoints and apoptosis.
• Pharmacology: Serves as a reference standard and positive control in experiments designed to test the efficacy of novel anti-mitotic agents.
• Chemical Biology: Used to probe kinase signaling pathways and protein-protein interactions related to cell division.

Basic Information

Product Name	Monastrol
CAS No.	254753-54-3
Molecular Formula	C₁₄H₁₄N₂O₃S
Molecular Weight	290.34 g/mol
Synonyms	Monastrol; (S)-Monastrol; (S)-2-(3-Hydroxy-4-methoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepine; Eg5 Kinesin Inhibitor; 2,3-Dihydro-2-(3-hydroxy-4-methoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-1,5-benzothiazepine; 1,5-Benzothiazepine derivative
EINECS	Contact for details

Quality Control

Our Monastrol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support research and development with material traceability and reliable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.