Description

8-(Trifluoromethyl)Quinoline-5-Carboxylic Acid is a high-value, multifunctional heterocyclic building block prized for its unique trifluoromethyl-substituted quinoline scaffold. This compound is critical for introducing specific steric, electronic, and lipophilic properties into advanced molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a key intermediate in the synthesis of complex active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research, where the trifluoromethyl group can enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the quinoline core for bioactivity and the fluorine atoms for improved environmental persistence and uptake.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of specialty polymers, organic semiconductors, and liquid crystals, where its aromatic system and fluorine content modify electronic properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, catalysis studies, and the exploration of new fluorinated heterocyclic chemistry.
• Ligand and Catalyst Design: The carboxylic acid and nitrogen moieties make it a versatile starting point for synthesizing chelating ligands and organocatalysts used in asymmetric synthesis.
• Fluorine-19 NMR Probe: Can be utilized as a molecular tag or probe in biochemical and diagnostic research due to the distinct 19F NMR signal of the trifluoromethyl group.

Basic Information

Product Name	8-(Trifluoromethyl)Quinoline-5-Carboxylic Acid
CAS No.	253787-47-2
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	5-Quinolinecarboxylic acid, 8-(trifluoromethyl)-; 8-Trifluoromethylquinoline-5-carboxylic acid; 8-(Trifluoromethyl)-5-quinolinecarboxylic acid; 253787-47-2; Quinoline-5-carboxylic acid, 8-(trifluoromethyl)-; 8-CF3-Quinoline-5-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl)Quinoline-5-Carboxylic Acid is manufactured under strict quality control protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure consistency and compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.