Description

Ac-Cys(Dodecyl)-Chloromethylketone is a specialized cysteine protease inhibitor featuring a dodecyl (C12) chain and a chloromethyl ketone reactive group. This compound is of significant value in biochemical and pharmaceutical research for its potent and irreversible inhibition of specific cysteine proteases, a key enzyme class involved in numerous biological processes. It is primarily needed by researchers in protease mechanism studies, drug discovery programs, and biochemical assay development.

Application

• Biochemical Research: As a potent, irreversible active-site inhibitor for mechanistic studies of cysteine proteases like cathepsins.
• Drug Discovery: Used as a chemical tool or lead compound in the development of therapeutic agents targeting protease-related diseases.
• Enzyme Assay Development: Serves as a positive control or validation standard in high-throughput screening (HTS) assays for protease activity.
• Proteomics: Employed to selectively label or inhibit cysteine proteases in complex biological samples for functional analysis.
• Academic Research: Fundamental studies in enzymology, cell biology, and pathology to understand protease function.

Basic Information

Product Name	Ac-Cys(Dodecyl)-Chloromethylketone
CAS No.	253589-60-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Acetyl-S-dodecyl-L-cysteine chloromethyl ketone; Ac-Cys(C12)-CMK; Cysteine Protease Inhibitor with C12 Alkyl Chain; S-Dodecyl-N-acetylcysteine chloromethyl ketone; L-Cysteine, N-acetyl-S-dodecyl-, chloromethyl ketone; Irreversible Cysteine Protease Inhibitor (C12); Cathepsin Inhibitor (C12 analog)
EINECS	Contact for details

Quality Control

Our Ac-Cys(Dodecyl)-Chloromethylketone is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.